Farnesol, a Morphogenetic Autoregulatory Substance in the Dimorphic Fungus Candida Albicans, Inhibits Hyphae Growth Through Suppression of a Mitogen-Activated Protein Kinase Cascade

Biol Pharm Bull. 2004 May;27(5):751-2. doi: 10.1248/bpb.27.751.

Abstract

Candida albicans grew in hyphal form in RPMI1640, however, addition of farnesol inhibited the formation. Farnesol did not affect the expression of mRNAs related to cAMP-EFG1 pathways. The mRNAs (HST7 and CPH1) in mitogen activated protein kinase (MAP) cascades were decreased in farnesol-treated cells, but CST20 was not. Furthermore, expression of general amino acid permease 1 (GAP1) was decreased by farnesol. We concluded that farnesol inhibits a MAP kinase cascades, and the suppression is a cause of interruption of hyphae formation.

Publication types

  • Comparative Study

MeSH terms

  • Antifungal Agents* / pharmacology
  • Candida albicans / drug effects*
  • Candida albicans / enzymology
  • Candida albicans / growth & development*
  • Farnesol / pharmacology*
  • Homeostasis / drug effects*
  • Homeostasis / physiology
  • Hyphae / drug effects*
  • Hyphae / enzymology
  • Hyphae / growth & development
  • MAP Kinase Signaling System / drug effects*
  • MAP Kinase Signaling System / physiology

Substances

  • Antifungal Agents
  • Farnesol