Treatment of Wilms tumor-related hypertension with losartan and captopril

Pediatr Nephrol. 2004 Jul;19(7):805-7. doi: 10.1007/s00467-004-1483-3. Epub 2004 May 6.

Abstract

Hypertension is commonly associated with Wilms tumor, but hypertension secondary to renin-secreting Wilms tumor is uncommon. We present an infant with severe hypertension and renin hypersecretion, which was resistant to multiple antihypertensive agents. Blood pressure was eventually controlled with a combination of captopril and losartan.

Publication types

  • Case Reports

MeSH terms

  • Angiotensin II Type 1 Receptor Blockers / therapeutic use*
  • Angiotensin-Converting Enzyme Inhibitors / therapeutic use*
  • Captopril / therapeutic use*
  • Humans
  • Hypertension / drug therapy*
  • Hypertension / etiology*
  • Infant
  • Kidney Neoplasms / complications*
  • Kidney Neoplasms / metabolism
  • Losartan / therapeutic use*
  • Male
  • Renin / metabolism
  • Wilms Tumor / complications*
  • Wilms Tumor / metabolism

Substances

  • Angiotensin II Type 1 Receptor Blockers
  • Angiotensin-Converting Enzyme Inhibitors
  • Captopril
  • Renin
  • Losartan