A nutritional supplement for improving fertility in women: a pilot study

J Reprod Med. 2004 Apr;49(4):289-93.


Objective: To determine the impact of nutritional supplementation on optimization of reproductive health in women.

Study design: A double-blind, placebo-controlled pilot study was initiated to determine the effects of FertilityBlend (Daily Wellness Co., Sunnyvale, California), a proprietary nutritional supplement containing chasteberry and green tea extracts, L-arginine, vitamins (including folate) and minerals. Changes in progesterone level, basal body temperature, menstrual cycle, pregnancy rate and side effects were monitored.

Results: Thirty women aged 24-46 years who had tried unsuccessfully to conceive for 6-36 months completed the study. After 3 months, the supplement group (n = 15) demonstrated a trend toward an increase in mean midluteal phase progesterone level (from 8.2 to 12.8 ng/mL, P = .08) and a significant increase in the average number of days in the cycle with basal temperatures >37 degrees C during the luteal phase (6.8-9.7 days, P = .04). The placebo group (n = 15) did not show any notable changes after treatment in any of the parameters studied. After 5 months, 5 of the 15 women in the supplement group were pregnant (33%), and none of the 15 women in the placebo group were (P <.01). No significant side effects were noted.

Conclusion: Nutritional supplementation may provide an attractive alternative or complement to conventional fertility therapy.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Arginine
  • Body Temperature
  • Complementary Therapies
  • Dietary Supplements* / adverse effects
  • Double-Blind Method
  • Female
  • Fertility Agents, Female / adverse effects
  • Fertility Agents, Female / pharmacology*
  • Humans
  • Infertility, Female / drug therapy*
  • Menstruation
  • Middle Aged
  • Minerals
  • Placebos
  • Plant Extracts
  • Pregnancy
  • Progesterone / blood
  • Vitamins


  • Fertility Agents, Female
  • Minerals
  • Placebos
  • Plant Extracts
  • Vitamins
  • Progesterone
  • Arginine