Postprandial effects of wine consumption on lipids and oxidative stress biomarkers

Drugs Exp Clin Res. 2003;29(5-6):217-23.


Postprandial lipemia has been recognized as a risk factor for atherosclerosis development. Consuming meals with suitable sources of antioxidants such as red wine reduces postprandial oxidative stress. However, information about the postprandial effects of wine ingestion outside meals on lipids and on in vivo low-density lipoprotein (LDL) oxidation in humans is scarce. The aim of this study was to investigate postprandial changes in lipids and in vivo LDL oxidation after moderate (250 ml) red wine ingestion, before and after sustained wine consumption of 250 ml/day for 4 days. After 4 days of sustained wine consumption a decrease in the LDL/high-density lipoprotein cholesterol ratio was observed after wine ingestion (p = 0.026). On day 4, a decrease in oxidized LDL levels and an increase in the antioxidant enzyme glutathione peroxidase activity (p = 0.025) were observed after wine ingestion. Our results show that consumption of red wine at moderate doses outside meals does not promote oxidative stress. Daily consumption of moderate doses of red wine can improve postprandial lipid profile and oxidative status when wine is ingested outside meals.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Alcohol Drinking / metabolism*
  • Cholesterol, HDL / blood*
  • Cholesterol, LDL / blood*
  • Dose-Response Relationship, Drug
  • Food-Drug Interactions*
  • Glutathione Peroxidase / metabolism
  • Humans
  • Male
  • Oxidative Stress / drug effects*
  • Postprandial Period*
  • Time Factors
  • Wine*


  • Cholesterol, HDL
  • Cholesterol, LDL
  • Glutathione Peroxidase