Nucleotide sugar interconversions and cell wall biosynthesis: how to bring the inside to the outside

Curr Opin Plant Biol. 2004 Jun;7(3):277-84. doi: 10.1016/j.pbi.2004.03.004.


Plants possess a sophisticated sugar biosynthetic machinery comprising families of nucleotide sugar interconversion enzymes. Literature published in the past two years has made a major contribution to our knowledge of the enzymes and genes involved in the interconversion of nucleotide sugars that are required for cell wall biosynthesis, including UDP-L-rhamnose, UDP-D-galactose, UDP-D-glucuronic acid, UDP-D-xylose, UDP-D-apiose, UDP-L-arabinose, GDP-L-fucose and GDP-L-galactose. Indirect evidence suggests that enzyme activity is crudely regulated at the transcriptional level in a cell-type and differentiation-dependent manner. However, feedback inhibition and NAD(+)/NADH redox control, as well as the formation of complexes between differentially encoded isoforms and glycosyltransferases, might fine-tune cell wall matrix biosynthesis. I hypothesise that the control of nucleotide sugar interconversion enzymes regulates glycosylation patterns in response to developmental, metabolic and stress-related stimuli, thereby linking signalling with primary metabolism and the dynamics of the extracellular matrix.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Arabidopsis / enzymology
  • Arabidopsis / genetics
  • Arabidopsis / metabolism
  • Carbon / metabolism
  • Cell Wall / metabolism*
  • Gene Expression Regulation, Plant
  • Glycosylation
  • Isoenzymes
  • Nucleoside Diphosphate Sugars / metabolism*
  • Oxidation-Reduction
  • Oxidoreductases / metabolism
  • Plants / metabolism*


  • Isoenzymes
  • Nucleoside Diphosphate Sugars
  • Carbon
  • Oxidoreductases