Effects of marine beta-1,3 glucan on immune reactions

Int Immunopharmacol. 2004 Jun;4(6):721-30. doi: 10.1016/j.intimp.2004.02.007.

Abstract

Glucans have a long history as nonspecific biological modulators. A novel glucan-Phycarine-was isolated from sporophytes of Laminaria digitata. Phycarine showed significant stimulation of phagocytic activity as well as potentiation of synthesis and release of IL-1, IL-6 and TNF-alpha. In addition, Phycarine increased NK cell-mediated killing of tumor cells both in vitro and in vivo while acting via complement receptor type 3 (CR3) receptors.

MeSH terms

  • Animals
  • Antigens, CD / biosynthesis
  • Antineoplastic Agents / pharmacology
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Cytokines / biosynthesis
  • Flow Cytometry
  • Fluorescent Antibody Technique
  • Humans
  • Immunity / drug effects*
  • Immunologic Factors / pharmacology*
  • In Vitro Techniques
  • Killer Cells, Natural / drug effects
  • Lentinan / pharmacology
  • Macrophage-1 Antigen / drug effects
  • Mice
  • Mice, Inbred BALB C
  • Neutrophils / drug effects
  • Phagocytosis / drug effects
  • beta-Glucans / pharmacology*

Substances

  • Antigens, CD
  • Antineoplastic Agents
  • Cytokines
  • Immunologic Factors
  • Macrophage-1 Antigen
  • beta-Glucans
  • Lentinan
  • beta-1,3-glucan