Abstract
Glucans have a long history as nonspecific biological modulators. A novel glucan-Phycarine-was isolated from sporophytes of Laminaria digitata. Phycarine showed significant stimulation of phagocytic activity as well as potentiation of synthesis and release of IL-1, IL-6 and TNF-alpha. In addition, Phycarine increased NK cell-mediated killing of tumor cells both in vitro and in vivo while acting via complement receptor type 3 (CR3) receptors.
Copyright 2004 Elsevier B.V.
MeSH terms
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Animals
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Antigens, CD / biosynthesis
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Antineoplastic Agents / pharmacology
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Cell Line, Tumor
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Cell Survival / drug effects
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Cytokines / biosynthesis
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Flow Cytometry
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Fluorescent Antibody Technique
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Humans
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Immunity / drug effects*
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Immunologic Factors / pharmacology*
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In Vitro Techniques
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Killer Cells, Natural / drug effects
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Lentinan / pharmacology
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Macrophage-1 Antigen / drug effects
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Mice
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Mice, Inbred BALB C
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Neutrophils / drug effects
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Phagocytosis / drug effects
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beta-Glucans / pharmacology*
Substances
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Antigens, CD
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Antineoplastic Agents
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Cytokines
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Immunologic Factors
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Macrophage-1 Antigen
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beta-Glucans
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Lentinan
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beta-1,3-glucan