A pilot study using synthetic feline facial pheromone for the management of feline idiopathic cystitis

J Feline Med Surg. 2004 Jun;6(3):133-8. doi: 10.1016/j.jfms.2004.01.006.


Synthetic feline facial pheromone (FFP) (Feliway; Ceva Animal Health) was assessed for the management of cats with recurrent feline idiopathic cystitis (FIC). Nine of 12 cats completed the randomised, double-blinded, placebo-controlled, crossover pilot study. They had their environment treated daily with either FFP or placebo for 2 months, after which time the treatment groups were reversed. Owners used visual analogue scales to define the severity of their cat's clinical signs and behavioural changes. Five (56%) of the owners stated that their cat's overall health was better when they were using FFP. Four (44%) of the owners noticed no difference between when using the FFP and when using the placebo. While there were no statistical differences between the two treatment groups there was a trend for the cats exposed to FFP to show fewer days with clinical signs of cystitis (FFP total, mean per cat+/-standard deviation, 30, 4.3+/-6.7; placebo 69, 9.9+/-19.1), a lower overall clinical score (1667, 238+/-476; 2009, 287+/-425), a reduced number of episodes of cystitis (9, 1.3+/-2.0; 10, 1.4+/-2.1) and reduced negative behavioural traits (e.g., less aggression and fear) (-128, -18.3+/-65.8; -73, -10.4+/-35.1).

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animal Husbandry
  • Animals
  • Cat Diseases / prevention & control*
  • Cats
  • Cross-Over Studies
  • Cystitis / prevention & control
  • Cystitis / veterinary*
  • Double-Blind Method
  • Eliminative Behavior, Animal / drug effects*
  • Female
  • Male
  • Pain Measurement / veterinary
  • Pheromones / administration & dosage*
  • Pilot Projects
  • Recurrence
  • Treatment Outcome


  • Pheromones