Usefulness of the third heart sound in predicting an elevated level of B-type natriuretic peptide

Am J Cardiol. 2004 May 15;93(10):1312-3. doi: 10.1016/j.amjcard.2004.01.074.


Third heart sounds were sought in 100 consecutive outpatients who had B-type natriuretic peptide (BNP) levels measured within 8 hours. Mean BNP levels were significantly higher in those with a third heart sound. The presence of a third heart sound was 41% sensitive and 97% specific for elevated BNP levels.

Publication types

  • Evaluation Study

MeSH terms

  • Aged
  • Auscultation / methods*
  • Double-Blind Method
  • Female
  • Heart Diseases / blood*
  • Heart Diseases / diagnosis*
  • Humans
  • Male
  • Natriuretic Peptide, Brain / blood*
  • Predictive Value of Tests
  • Prospective Studies
  • Sensitivity and Specificity


  • Natriuretic Peptide, Brain