The relationship between high-sensitive C-reactive protein and pulse wave velocity in healthy Japanese men

Atherosclerosis. 2004 Jun;174(2):373-7. doi: 10.1016/j.atherosclerosis.2004.01.032.


Although pulse wave velocity (PWV) and high-sensitive C-reactive protein (hsCRP) are known as predictors of future cardiovascular events, their association has not been examined. The present study was conducted to evaluate their association in the general population. In 2668 Japanese men (43 +/- 10 years old), PWV was obtained by volume rendering methods, and hsCRP was determined by the latex aggregation method. PWV showed a significant correlation with logarithm of hsCRP (r = 0.06, P < 0.01). The concentration of hsCRP in the highest quartile of PWV was higher than that in the other three groups (P < 0.01). However, multiple linear regression analyses demonstrated that logarithm of hsCRP was not significantly related to PWV, independent from conventional risk factors. Calculated Framingham risk score (FRS) was higher in the highest quartiles of both hsCRP and PWV than in the other groups (P < 0.05). Thus, while increased hsCRP related to increased PWV, they may be independent predictors of atherosclerotic cardiovascular risk. A prospective study to confirm the independency of their significance in predicting future cardiovascular events and to evaluate the usefulness of the combination of both parameters to screen subjects for cardiovascular risk is necessary.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Blood Chemical Analysis
  • Blood Flow Velocity / physiology*
  • Body Mass Index
  • C-Reactive Protein / analysis*
  • Cohort Studies
  • Coronary Disease / physiopathology*
  • Humans
  • Japan
  • Linear Models
  • Male
  • Middle Aged
  • Probability
  • Reference Values
  • Sampling Studies
  • Vascular Patency
  • Vascular Resistance


  • C-Reactive Protein