Tobacco carcinogen-induced cellular transformation increases Akt activation in vitro and in vivo

Chest. 2004 May;125(5 Suppl):101S-2S. doi: 10.1378/chest.125.5_suppl.101s.

Authors

Kip A West¹, Ilona R Linnoila, John Brognard, Steven Belinsky, Curtis Harris, Phillip A Dennis

Affiliation

¹ Cancer Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20889-5105, USA.

PMID: 15136436
DOI: 10.1378/chest.125.5_suppl.101s

No abstract available

MeSH terms

Animals
Apoptosis
Carcinogens
Cell Transformation, Neoplastic / metabolism*
Cells, Cultured
Enzyme Activation
ErbB Receptors / metabolism
Humans
Lung Neoplasms / enzymology*
Lung Neoplasms / prevention & control
Mice
Mice, Inbred A
Nitrosamines
Phosphorylation
Protein Serine-Threonine Kinases / antagonists & inhibitors
Protein Serine-Threonine Kinases / metabolism*
Proto-Oncogene Proteins / antagonists & inhibitors
Proto-Oncogene Proteins / metabolism*
Proto-Oncogene Proteins c-akt

Substances

Carcinogens
Nitrosamines
Proto-Oncogene Proteins
4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone
ErbB Receptors
AKT1 protein, human
Protein Serine-Threonine Kinases
Proto-Oncogene Proteins c-akt