Striatal dopamine transporter in dementia with Lewy bodies and Parkinson disease: a comparison

Neurology. 2004 May 11;62(9):1568-72. doi: 10.1212/01.wnl.0000123248.39847.1d.


Objective: To study the nigrostriatal pathways in 21 patients with dementia with Lewy bodies (DLB), 19 drug naive Parkinson disease (PD) patients, and 16 controls using a dopaminergic presynaptic ligand [123I]-2beta-carbometoxy-3beta-(4-iodophenyl)-N-(3-fluoropropyl) nortropane (FP-CIT) and SPECT in order to assess similarities or differences between DLB and PD.

Methods: A SPECT scan was carried out 3 to 4 hours after administration of 185 MBq (IV) of FP-CIT. Using occipital cortex as a radioactivity uptake reference, ratios for the caudate nuclei and the anterior and posterior putamina of both hemispheres were calculated. From the FP-CIT binding measurements, asymmetry indices and caudate:putamen ratios were derived.

Results: The DLB and PD groups had lower FP-CIT binding in all striatal areas than controls (analysis of variance: p < 0.001 in all measures). DLB patients also had significantly lower binding in the caudate nucleus than the PD patients. There was greater asymmetry of uptake in the posterior putamina of PD patients than DLB patients (p < 0.04) and controls (p < 0.01). The mean caudate:putamen ratio for the DLB group was not significantly different from that of the controls, while the mean caudate:putamen ratio of the PD group was higher than that of the control group (p < 0.001) and the DLB group (p < 0.001).

Conclusion: This study showed differences between PD and DLB in the pattern of striatal dopaminergic dysfunction. DLB patients do not have the characteristic selective degeneration of ventrolateral nigral neurons seen in PD. This could explain some of the clinical differences between DLB and PD.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Caudate Nucleus / diagnostic imaging
  • Caudate Nucleus / metabolism
  • Corpus Striatum / diagnostic imaging
  • Corpus Striatum / metabolism*
  • Dopamine / metabolism
  • Dopamine Plasma Membrane Transport Proteins
  • Functional Laterality
  • Humans
  • Lewy Body Disease / diagnosis
  • Lewy Body Disease / diagnostic imaging
  • Lewy Body Disease / metabolism*
  • Membrane Glycoproteins / metabolism*
  • Membrane Transport Proteins / metabolism*
  • Nerve Tissue Proteins / metabolism*
  • Neurologic Examination
  • Occipital Lobe / diagnostic imaging
  • Occipital Lobe / metabolism
  • Parkinson Disease / diagnosis
  • Parkinson Disease / diagnostic imaging
  • Parkinson Disease / metabolism*
  • Psychiatric Status Rating Scales
  • Putamen / diagnostic imaging
  • Putamen / metabolism
  • Severity of Illness Index
  • Striatonigral Degeneration / diagnostic imaging
  • Striatonigral Degeneration / metabolism
  • Tomography, Emission-Computed, Single-Photon
  • Tropanes


  • Dopamine Plasma Membrane Transport Proteins
  • Membrane Glycoproteins
  • Membrane Transport Proteins
  • Nerve Tissue Proteins
  • Tropanes
  • 2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane
  • Dopamine