Effects of nicotine on cognitive deficits in schizophrenia

Neuropsychopharmacology. 2004 Jul;29(7):1378-85. doi: 10.1038/sj.npp.1300450.


Several lines of evidence suggest a pathophysiological role for nicotinic receptors in schizophrenia. Activation by nicotine alters physiological dysfunctions, such as eye movement and sensory gating abnormalities, but effects on neuropsychological performance are just beginning to be investigated. Nicotine-induced desensitization and the well-known tachyphylaxis of nicotinic receptors may confound such efforts. In all, 20 schizophrenics, 10 smokers, and 10 nonsmokers were assessed following the administration of nicotine gum and placebo gum. The Repeatable Battery for the Assessment of Neuropsychological Status was administered. Nicotine affected only the Attention Index; there were no effects on learning and memory, language, or visuospatial/constructional abilities. Attentional function was increased in nonsmokers, but decreased in nicotine-abstinent smokers after nicotine administration. The effects of nicotine in schizophrenia do not extend to all areas of cognition. Effects on attention may be severely limited by tachyphylaxis, such that decremented performance occurs in smokers, while modest effects may be achieved in nonsmokers.

Publication types

  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Attention / drug effects
  • Chewing Gum
  • Cognition Disorders / drug therapy*
  • Cognition Disorders / etiology
  • Female
  • Humans
  • Male
  • Middle Aged
  • Neuropsychological Tests
  • Nicotine / blood
  • Nicotine / therapeutic use*
  • Nicotinic Agonists / blood
  • Nicotinic Agonists / therapeutic use*
  • Psychomotor Performance / drug effects
  • Reaction Time / drug effects
  • Schizophrenia / complications*
  • Single-Blind Method
  • Smoking / drug therapy
  • Time Factors
  • Verbal Behavior / drug effects


  • Chewing Gum
  • Nicotinic Agonists
  • Nicotine