The myelinated axon is dependent on the myelinating cell for support and maintenance: molecules involved

J Neurosci Res. 2004 Jun 1;76(5):593-8. doi: 10.1002/jnr.20063.


The myelin-forming cells, oligodendrocytes and Schwann cells, extend processes that spirally wrap axons and provide the insulation that allows rapid saltatory conduction. Recent data suggest a further role for the myelin-forming cells in axonal support and maintenance. This Mini-Review summarises some of the data that support this view and highlights the molecules involved.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Axons / physiology*
  • Demyelinating Diseases / physiopathology
  • Humans
  • Myelin Proteins / physiology
  • Nerve Fibers, Myelinated / physiology*
  • Oligodendroglia / physiology*
  • Protein Transport
  • Schwann Cells / physiology*


  • Myelin Proteins