Reduced natural killer cell activity in multi-drug resistant pulmonary tuberculosis

Scand J Immunol Suppl. 1992:11:167-70. doi: 10.1111/j.1365-3083.1992.tb01643.x.


Cellular immune status in five patients with multi-drug resistant pulmonary tuberculosis was investigated and compared with five matched controls with non-resistant tuberculosis. A significant reduction in fresh natural killer (NK)-cell activity was found in the resistant group (P less than 0.005). There were no significant differences between the two groups in lymphocyte phenotype, proliferation or PPD-specific cytotoxicity. Reduced NK-cell function may play a role in the pathogenesis of multi-drug resistant pulmonary tuberculosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cytotoxicity, Immunologic
  • Drug Resistance
  • Humans
  • Killer Cells, Natural / immunology*
  • Tuberculosis, Pulmonary / drug therapy
  • Tuberculosis, Pulmonary / immunology*