p53 at codon 72 polymorphism, human papillomavirus infection and cervical lesions: a cross-sectional study from northeastern Italy

Eur J Obstet Gynecol Reprod Biol. 2004 Jun 15;114(2):210-4. doi: 10.1016/j.ejogrb.2003.10.021.


Objective: To test the hypothesis that p53 homozygous Arg/Arg genotype at codon 72 is a significant risk factor for the development of HPV induced cervical cancer.

Study design: A cross-sectional survey on p53 allelotypes distribution in women with different grade of cervical lesions and with or without HPV infection, in comparison to the distribution on a control group of women cytologically normal and HPV negative.

Results: No statistically significant difference in the p53 polymorphism distribution was found in relation to the infection with HPV, the cytological pattern and both conditions. A modest but constant over-representation of Pro-allelotypes was found in all groups in comparison to the control group.

Conclusion: Searching for p53 polymorphism in a clinical setting does not seem to support secondary prevention procedures, at least for women in this area.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Alleles
  • Analysis of Variance
  • Codon*
  • Cross-Sectional Studies
  • Female
  • Genotype
  • Humans
  • Italy
  • Papillomaviridae / genetics
  • Papillomavirus Infections / genetics*
  • Polymorphism, Genetic*
  • Tumor Suppressor Protein p53 / genetics*
  • Uterine Cervical Neoplasms / genetics*
  • Uterine Cervical Neoplasms / pathology
  • Uterine Cervical Neoplasms / virology*


  • Codon
  • Tumor Suppressor Protein p53