Vertebral axial decompression (VAX-D) is capable of reducing intradiscal pressure to the negative range. The purpose of this study was to compare the effects of two dosage regimens of VAX-D treatments on the level of low back pain in patients who were referred to a neurosurgical practice after failing standard medical therapy. In this study, one group of patients received an average course of treatment consisting of 18 daily sessions and another group received half that number of daily treatment sessions. The treatment parameters for all patients differed only in the number of sessions. Seventy-six percent of the higher dosage group achieved remission of low back pain compared to 43% of the lower dosage group. Chi-squared analysis revealed that the differences in response in the two dosage groups were statistically significant at p< 0.0001.