Polymorphisms of the ADAM33 gene are associated with accelerated lung function decline in asthma

Clin Exp Allergy. 2004 May;34(5):757-60. doi: 10.1111/j.1365-2222.2004.1938.x.


Background: Asthma is a genetically complex disease characterized by respiratory symptoms, intermittent airway obstruction and airway hyper-responsiveness due to airway inflammation and remodelling. The ADAM33 gene is associated with asthma and airway hyper-responsiveness and is postulated as a gene for airway remodelling.

Objective: To investigate whether polymorphisms of the ADAM33 gene are associated with accelerated lung function decline in patients with asthma.

Methods: In a cohort of 200 asthma patients followed over 20 years, eight single nucleotide polymorphisms of the ADAM33 gene were analysed to estimate their effect on annual FEV(1) decline.

Results: The rare allele of the S_2 polymorphism was significantly associated with excess decline in FEV(1) (P<0.05).

Conclusion: These findings suggest that a variant in ADAM33 is not only important in the development of asthma but also in disease progression, possibly related to enhanced airway remodelling.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • ADAM Proteins
  • Adolescent
  • Adult
  • Aging / physiology*
  • Asthma / genetics*
  • Asthma / physiopathology*
  • Disease Progression
  • Forced Expiratory Volume
  • Genetic Predisposition to Disease
  • Humans
  • Longitudinal Studies
  • Lung / physiopathology*
  • Metalloendopeptidases / genetics*
  • Polymorphism, Genetic*
  • Polymorphism, Single Nucleotide


  • ADAM Proteins
  • ADAM33 protein, human
  • Metalloendopeptidases