beta-Blockers in hypertension: is carvedilol different?

Am J Cardiol. 2004 May 6;93(9A):7B-12B. doi: 10.1016/j.amjcard.2004.01.020.

Abstract

Most studies assessing the effects of beta-blockers were carried out with traditional, beta(1)-selective beta-blockers, such as metoprolol and atenolol. Pathophysiologic and pharmacologic studies have documented that not all beta-blockers are created equal. In particular, the pharmacologic and clinical profiles of the newer, vasodilating beta-blockers, such as carvedilol, have been shown to differ from those of the traditional beta-blockers. These differences, although relevant in the younger patient with hypertension, are particularly important in elderly patients in whom traditional beta-blockers may not be as effective or as well tolerated as the newer vasodilating agents.

Publication types

  • Review

MeSH terms

  • Adrenergic beta-Antagonists / pharmacology*
  • Antihypertensive Agents / pharmacology*
  • Carbazoles / pharmacology*
  • Carvedilol
  • Hemodynamics / drug effects
  • Humans
  • Hypertension / drug therapy*
  • Propanolamines / pharmacology*

Substances

  • Adrenergic beta-Antagonists
  • Antihypertensive Agents
  • Carbazoles
  • Propanolamines
  • Carvedilol