Proton therapy for prostate cancer: the initial Loma Linda University experience

Int J Radiat Oncol Biol Phys. 2004 Jun 1;59(2):348-52. doi: 10.1016/j.ijrobp.2003.10.011.


Purpose: We analyzed results of conformal proton radiation therapy for localized prostate cancer, with emphasis on biochemical freedom from relapse.

Methods and materials: Analyses were performed for 1255 patients treated between October 1991 and December 1997. Outcomes were measured on primarily in terms of biochemical relapse and toxicity.

Results: The overall biochemical disease-free survival rate was 73%, and was 90% in patients with initial PSA <or=4.0; it was 87% in patients with posttreatment PSA nadirs <or=0.50. Rates dropped with rises in initial and nadir PSA values. Long-term survival outcomes were comparable with those reported for other modalities intended for cure.

Conclusions: Conformal proton radiation therapy at the reported dose levels yielded disease-free survival rates comparable with other forms of local therapy, and with minimal morbidity. Dose-escalation strategies are being implemented to further improve long-term results.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Humans
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Photons / therapeutic use
  • Prostate-Specific Antigen / blood
  • Prostatic Neoplasms / blood
  • Prostatic Neoplasms / mortality
  • Prostatic Neoplasms / radiotherapy*
  • Proton Therapy*
  • Radiotherapy, Conformal*
  • Survival Rate


  • Prostate-Specific Antigen