Regulation of local mRNA translation

Curr Opin Cell Biol. 2004 Jun;16(3):308-13. doi: 10.1016/


Regulated local mRNA translation is one mechanism cells employ to concentrate proteins in particular locations. However, cells use many different strategies to accomplish this task; for example, some mRNAs are destroyed in regions where they are not wanted, other mRNAs are repressed in areas where their translation would be deleterious, and yet other mRNAs are transported, in a quiescent state, to the sites where their translation is activated. The importance of local translation cannot be overstated, for, depending on the species or cell type, it is required for cell division, establishment of mating type, development and memory formation.

Publication types

  • Review

MeSH terms

  • Animals
  • DNA-Binding Proteins / genetics
  • Drosophila Proteins / genetics
  • Fragile X Mental Retardation Protein
  • Gene Expression Regulation*
  • Humans
  • Nerve Tissue Proteins / genetics
  • Protein Biosynthesis / genetics*
  • RNA Transport
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • RNA-Binding Proteins / genetics
  • Repressor Proteins / genetics
  • Saccharomyces cerevisiae Proteins / genetics
  • Transcription Factors / genetics
  • Transcription, Genetic
  • Xenopus Proteins / genetics
  • mRNA Cleavage and Polyadenylation Factors


  • ASH1 protein, S cerevisiae
  • Cpeb1 protein, Xenopus
  • DNA-Binding Proteins
  • Drosophila Proteins
  • FMR1 protein, human
  • Nerve Tissue Proteins
  • RNA, Messenger
  • RNA-Binding Proteins
  • Repressor Proteins
  • Saccharomyces cerevisiae Proteins
  • Transcription Factors
  • Xenopus Proteins
  • mRNA Cleavage and Polyadenylation Factors
  • Fragile X Mental Retardation Protein
  • nos protein, Drosophila