Disappearance of specific immune response after successful therapy of chronic Lyme borreliosis

Int J Med Microbiol. 2004 Apr;293 Suppl 37:161-4. doi: 10.1016/s1433-1128(04)80031-7.


512 consecutive patients suffering from chronic Lyme borreliosis have been treated according to a standardized therapy regimen which was developed using the results of a controlled trial (Hassler et al., 1990; Hassler, 1992). Follow up was performed for at least 6 (maximum 16) years. In the first two years after initial therapy clinical and serological data were collected every six months including Western blot testing, later once a year.

MeSH terms

  • Anti-Bacterial Agents / therapeutic use*
  • Antibodies, Bacterial / blood
  • Blotting, Western
  • Borrelia burgdorferi / immunology*
  • Cefotaxime / therapeutic use*
  • Follow-Up Studies
  • Humans
  • Lyme Disease / drug therapy
  • Lyme Disease / immunology*


  • Anti-Bacterial Agents
  • Antibodies, Bacterial
  • Cefotaxime