Structural basis of single-stranded RNA recognition

Acc Chem Res. 2004 May;37(5):279-87. doi: 10.1021/ar030034m.


RNA is an ancient and highly versatile molecule that plays fundamental roles in all living organisms. Its molecular functions range from being a mediator of genetic information to the regulation of essential cellular processes. These functions are often accomplished in close association with RNA binding proteins. Over the past few years, a considerable number of high-resolution three-dimensional structures of important protein-RNA complexes have been determined. Here, we wish to discuss recent examples and highlight principles and distinct features of single-stranded RNA recognition by conserved RNA binding domains.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Models, Molecular
  • Nucleic Acid Conformation
  • RNA / chemistry*
  • RNA / physiology


  • RNA