Variant MYST4-CBP gene fusion in a t(10;16) acute myeloid leukaemia

Br J Haematol. 2004 Jun;125(5):601-4. doi: 10.1111/j.1365-2141.2004.04960.x.

Abstract

We report a novel fusion of the MYST4 and CBP genes in an acute myeloid leukaemia (AML)-M4 patient exhibiting t(10;16)(q22;p13) and t(11;17)(q23;q21). The t(10;16)(q22;p13) resulted in a rearrangement, where MYST4-CBP and CBP-MYST4 chimaeric transcripts were products of in-frame fusions of MYST4 exon 17 to CBP exon 6 and CBP exon 4 to MYST4 exon 18 respectively. The potential resulting chimaeric proteins showed similarities with MYST3-CBP, MYST3-P300 and MYST3-NCOA2 putative fusion proteins found in other cases of AML.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Disease
  • Artificial Gene Fusion
  • Chimera / genetics
  • Chromosomes, Human, Pair 10 / genetics*
  • Chromosomes, Human, Pair 16 / genetics*
  • Female
  • Gene Rearrangement / genetics
  • Humans
  • Leukemia, Myeloid / genetics*
  • Translocation, Genetic / genetics*