A new lead compound for abscisic acid biosynthesis inhibitors targeting 9-cis-epoxycarotenoid dioxygenase

Sun-Young Han; Nobutaka Kitahata; Tamio Saito; Masatomo Kobayashi; Kazuo Shinozaki; Shigeo Yoshida; Tadao Asami

doi:10.1016/j.bmcl.2004.04.035

A new lead compound for abscisic acid biosynthesis inhibitors targeting 9-cis-epoxycarotenoid dioxygenase

Bioorg Med Chem Lett. 2004 Jun 21;14(12):3033-6. doi: 10.1016/j.bmcl.2004.04.035.

Authors

Sun-Young Han¹, Nobutaka Kitahata, Tamio Saito, Masatomo Kobayashi, Kazuo Shinozaki, Shigeo Yoshida, Tadao Asami

Affiliation

¹ RIKEN Tsukuba Institute, Koyadai 3-1-1, Ibaraki, Tsukuba 305-0074, Japan.

PMID: 15149639
DOI: 10.1016/j.bmcl.2004.04.035

Abstract

9-cis-Epoxycarotenoid dioxygenase (NCED), a key enzyme in abscisic acid (ABA) biosynthesis, cleaves the olefinic double bond of 9-cis-epoxycarotenoid. Several analogues of nordihydroguaiaretic acid (NDGA) were designed and synthesized, and their efficacy as inhibitors of NCED was examined. One of the synthesized compounds (20) was found to be an inhibitor of this enzyme, and inhibited ABA accumulation and stomatal closing, suggesting that 20 should be ABA biosynthesis inhibitor.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Abscisic Acid / biosynthesis*
Dioxygenases
Drug Delivery Systems / methods*
Enzyme Inhibitors / administration & dosage
Enzyme Inhibitors / chemistry*
Oxygenases / antagonists & inhibitors*
Oxygenases / metabolism
Plant Leaves / enzymology
Plant Proteins
Spinacia oleracea / drug effects
Spinacia oleracea / enzymology

Substances

Enzyme Inhibitors
Plant Proteins
Abscisic Acid
Oxygenases
Dioxygenases
9-cis-epoxy-carotenoid dioxygenase