Abstract
The sesquineolignan, saucerneol B (1), and dineolignans, manassantin A (2), and manassantin B (3), were isolated from the methanol extracts of Saururus chinensis root and elucidated by their spectroscopic data analysis. Compounds 1-3 inhibited hACAT-1 and hACAT-2 with IC(50) values of 43.0 and 124.0 microM for 1, of 39.0 and 8.0 microM for 2, of 82.0 microM and only 32% inhibition at 1mM for 3, respectively. The EtOAc-soluble fraction, which contained compounds 1-3, of methanol extracts of S. chinensis exhibited strong cholesterol-lowering effect in high cholesterol-fed mice.
MeSH terms
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Animals
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / isolation & purification
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Enzyme Inhibitors / pharmacology
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Furans / chemistry
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Furans / isolation & purification
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Furans / pharmacology*
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Humans
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Lignans / chemistry
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Lignans / isolation & purification
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Lignans / pharmacology*
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Male
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Mice
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Mice, Inbred C57BL
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology
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Plant Roots
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Saururaceae*
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Sterol O-Acyltransferase / antagonists & inhibitors*
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Sterol O-Acyltransferase / metabolism
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Sterol O-Acyltransferase 2
Substances
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Enzyme Inhibitors
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Furans
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Lignans
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Plant Extracts
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manassantin B
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saucerneol B
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manassantin A
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Sterol O-Acyltransferase
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sterol O-acyltransferase 1