About GATA3, HNF3A, and XBP1, three genes co-expressed with the oestrogen receptor-alpha gene (ESR1) in breast cancer

Mol Cell Endocrinol. 2004 Apr 30;219(1-2):1-7. doi: 10.1016/j.mce.2004.02.021.

Abstract

In breast tumours and breast cancer cell (BCC) lines, microarray analyses have revealed that a series of genes are expressed in close association with the oestrogen receptor-alpha (ER-alpha) gene, ESR1. Three of them, GATA3, HNF3A (also known as FOXA1), and XBP1 encode transcription factors. Here, we present these factors and we discuss their potential involvement in the ER-alpha-mediated actions in BCC. We notably show the relations that exist, or that might exist, between these factors and the oestrogen-inducible trefoil factor TFF1.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Breast Neoplasms / genetics*
  • Breast Neoplasms / metabolism
  • DNA-Binding Proteins / genetics*
  • DNA-Binding Proteins / metabolism
  • Estrogen Receptor alpha / genetics*
  • Estrogen Receptor alpha / metabolism
  • Female
  • GATA3 Transcription Factor
  • Gene Expression Regulation, Neoplastic
  • Hepatocyte Nuclear Factor 3-alpha
  • Humans
  • Molecular Sequence Data
  • Nuclear Proteins / genetics*
  • Nuclear Proteins / metabolism
  • Promoter Regions, Genetic / genetics
  • Proteins / genetics
  • Regulatory Factor X Transcription Factors
  • Trans-Activators / genetics*
  • Trans-Activators / metabolism
  • Transcription Factors / genetics*
  • Transcription Factors / metabolism
  • Trefoil Factor-1
  • Tumor Suppressor Proteins
  • X-Box Binding Protein 1

Substances

  • DNA-Binding Proteins
  • Estrogen Receptor alpha
  • FOXA1 protein, human
  • GATA3 Transcription Factor
  • GATA3 protein, human
  • Hepatocyte Nuclear Factor 3-alpha
  • Nuclear Proteins
  • Proteins
  • Regulatory Factor X Transcription Factors
  • TFF1 protein, human
  • Trans-Activators
  • Transcription Factors
  • Trefoil Factor-1
  • Tumor Suppressor Proteins
  • X-Box Binding Protein 1
  • XBP1 protein, human