Impaired response rates, but satisfying protection rates to influenza vaccination in dialysis patients

Vaccine. 2004 Jun 2;22(17-18):2199-201. doi: 10.1016/j.vaccine.2003.11.046.

Abstract

Dialysis patients show impaired responses to several vaccines. Limited recent data are available on influenza vaccination in these patients. In the 1998-1999 influenza season, 44 dialysis patients received a standard trivalent vaccination followed by a booster two months later. The serum antibody responses in these patients were compared with those found in healthy subjects. A fourfold rise in serum hemagglutination inhibition titre was achieved in 23-58% of all patients. Protective titres were reached in 53-93% of the patients. Since protective antibody titers can be induced, it is recommended to vaccinate dialysis patients annually against influenza.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Antibodies, Viral / blood*
  • Female
  • Hemagglutination Inhibition Tests
  • Humans
  • Immunization, Secondary
  • Influenza A virus / immunology*
  • Influenza B virus / immunology*
  • Influenza Vaccines / administration & dosage
  • Influenza Vaccines / immunology*
  • Influenza, Human / prevention & control*
  • Male
  • Renal Dialysis
  • Renal Insufficiency / immunology*
  • Vaccination*

Substances

  • Antibodies, Viral
  • Influenza Vaccines