Routine use of gradient-echo MRI to screen for cerebral amyloid angiopathy in elderly patients

AJR Am J Roentgenol. 2004 Jun;182(6):1547-50. doi: 10.2214/ajr.182.6.1821547.


Objective: The objective of this study was to evaluate the routine use of gradient-refocused echo MRI sequences in the detection of cortical cerebral microbleeding suggestive of cerebral amyloid angiopathy in elderly patients (> 70 years old).

Conclusion: The addition of gradient-refocused echo sequences to routine brain MRI resulted in the identification of cerebral amyloid angiopathy-related microbleeding in 15.5% of elderly patients. In most (86.7%) of these patients with positive findings, cerebral amyloid angiopathy was not suspected clinically, and 46.7% of these patients were undergoing anticoagulant or aspirin therapy, placing them at an increased risk of recurrent intracranial hemorrhage and catastrophic stroke.

MeSH terms

  • Aged
  • Cerebral Amyloid Angiopathy / diagnosis*
  • Female
  • Humans
  • Magnetic Resonance Imaging / methods*
  • Male