Enhanced oxidative stress in workers with a standing occupation

Occup Environ Med. 2004 Jun;61(6):548-50. doi: 10.1136/oem.2003.008805.


Background: Several epidemiological studies have shown a statistically significant association between standing work and chronic venous insufficiency of lower limbs. This condition has been associated with an enhanced oxidative stress that, according to the literature, could represent a risk factor for cardiovascular and other systemic diseases.

Aims and methods: To evaluate venous pressure of the lower limbs and reactive oxygen species (ROS) before and after work in 62 workers with a standing occupation (surgery room nurses) and 65 outpatient department nurses who can walk during their working time.

Results: After work, a statistically significant increase of venous pressure of the lower limbs levels was observed in both the study group and controls. Standing workers showed significantly higher mean levels of ROS after work.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Chronic Disease
  • Female
  • Humans
  • Male
  • Middle Aged
  • Nurses / statistics & numerical data
  • Occupational Diseases / epidemiology*
  • Oxidative Stress*
  • Posture
  • Reactive Oxygen Species / analysis*
  • Reactive Oxygen Species / blood
  • Risk Factors
  • Venous Insufficiency / blood
  • Venous Insufficiency / epidemiology*
  • Venous Pressure / physiology


  • Reactive Oxygen Species