Prostate Cancer and Body Size at Different Ages: An Italian Multicentre Case-Control Study

Br J Cancer. 2004 Jun 1;90(11):2176-80. doi: 10.1038/sj.bjc.6601859.

Abstract

We investigated the influence of anthropometric measures at diagnosis and at different ages on prostate cancer risk using an Italian multicentre case-control study conducted between 1991 and 2002 of 1294 histologically confirmed cases and 1451 controls admitted to the same network of hospitals for acute non-neoplastic conditions. Height, weight, body mass index (BMI), waist-to-hip ratio, lean body mass 1 year before diagnosis/interview were not significantly associated with risk. However, a positive association with high BMI at age 30 years was found (odds ratio=1.2 for BMI> or =24.7 vs <22.7) and: for less differentiated prostate cancer, with BMI 1 year before diagnosis/interview. This study supports possible relationships between high body mass in young adulthood, and a tendency to high weight throughout adult life, and the risk of prostate cancer.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Factors
  • Aged
  • Body Mass Index*
  • Case-Control Studies
  • Humans
  • Italy
  • Male
  • Middle Aged
  • Prostatic Neoplasms / etiology*
  • Prostatic Neoplasms / pathology
  • Risk Factors