Diabetes mellitus and prostate cancer risk among older men: population-based case-control study

Br J Cancer. 2004 Jun 1;90(11):2171-5. doi: 10.1038/sj.bjc.6601857.


We investigate the relation between diabetes mellitus and risk of prostate cancer among older (age 65-79 years) men in a population-based case-control study of 407 incident histologically confirmed cases registered in the South Carolina Central Cancer Registry between 1999 and 2001 (70.6% response rate); controls were 393 men identified through the Health Care Financing Administration Medicare beneficiary file for South Carolina in 1999 (63.8% response rate). After adjusting for age, race, and prostate cancer screening in the past 5 years, a history of diabetes mellitus was associated with a reduced risk of prostate cancer (adjusted odds ratio (aOR)=0.64; 95% confidence interval (CI)=0.45, 0.91). The protective effect was stronger for those with complications associated with diabetes (aOR=0.61; 95% CI=0.42, 0.90) and for African-American men (aOR=0.36; 95% CI=0.21, 0.62). Additional research is needed to understand the biologic mechanisms by which diabetes may influence prostate cancer risk; genetic factors may play an important role in understanding this association.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • African Americans
  • Age Factors
  • Aged
  • Case-Control Studies
  • Diabetes Complications
  • Diabetes Mellitus* / genetics
  • Epidemiologic Studies
  • Humans
  • Incidence
  • Male
  • Odds Ratio
  • Prostatic Neoplasms / epidemiology*
  • Prostatic Neoplasms / genetics
  • Prostatic Neoplasms / prevention & control*
  • Risk Factors