Efficient synthesis of poly(phenylazomethine) dendrons allowing access to higher generation dendrimers

Org Lett. 2004 May 27;6(11):1709-12. doi: 10.1021/ol049656d.


We have developed a novel synthetic method of phenylazomethine dendrons that uses 4,4'-methylenedianiline instead of 4,4'-diaminobenzophenone to synthesize the precursor of the phenylazomethine dendron and then oxidized the precursor to the next-generation dendron. For this method, the productivity of the dendrons has been significantly increased. Furthermore, as the synthesis of high-generation dendrons becomes easier, synthesis of DPA G5 was achieved. [structure--see text]