Mirtazapine for reducing nocturnal itch in patients with chronic pruritus: a pilot study

J Am Acad Dermatol. 2004 Jun;50(6):889-91. doi: 10.1016/j.jaad.2004.01.045.


Nocturnal pruritus is a significant problem for patients with inflammatory skin diseases and many systemic diseases. The oral therapies currently available have a limited effect. We present an open, uncontrolled pilot study of 3 patients with inflammatory skin diseases and severe nocturnal pruritus who underwent treatment with mirtazapine (Remeron), a noradrenergic and specific serotonergic antidepressant. Mirtazapine is a safe medication without serious side effects and may be an effective alternative for the treatment of nocturnal pruritus.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Adrenergic alpha-Antagonists / therapeutic use*
  • Antidepressive Agents, Tricyclic / therapeutic use*
  • Female
  • Humans
  • Mianserin / administration & dosage
  • Mianserin / analogs & derivatives*
  • Mianserin / therapeutic use*
  • Middle Aged
  • Mirtazapine
  • Pilot Projects
  • Pruritus / drug therapy*


  • Adrenergic alpha-Antagonists
  • Antidepressive Agents, Tricyclic
  • Mianserin
  • Mirtazapine