Treatment of extensive chronic cutaneous graft-versus-host disease in an infant with topical pimecrolimus

Mirjana Ziemer; Bernd Gruhn; Jens J Thiele; Peter Elsner

doi:10.1016/j.jaad.2004.02.010

Treatment of extensive chronic cutaneous graft-versus-host disease in an infant with topical pimecrolimus

J Am Acad Dermatol. 2004 Jun;50(6):946-8. doi: 10.1016/j.jaad.2004.02.010.

Authors

Mirjana Ziemer¹, Bernd Gruhn, Jens J Thiele, Peter Elsner

Affiliation

¹ Department of Dermatology, University of Jena, Jena, Germany. Mirjana.Ziemer@derma.uni-jena.de

PMID: 15153900
DOI: 10.1016/j.jaad.2004.02.010

Abstract

We report a case of generalized cutaneous chronic graft-versus-host disease in a 17-month-old infant. Topical treatment with the novel ascomycin substance pimecrolimus once daily for 4 weeks led to a near complete clearance of skin lesions. Importantly, this excellent clinical response was obtained without additional use of systemic immunosuppressive treatment.

Publication types

Case Reports

MeSH terms

Administration, Topical
Graft vs Host Disease / drug therapy*
Humans
Infant
Leukemia, Myelomonocytic, Acute / therapy
Male
Peripheral Blood Stem Cell Transplantation / adverse effects
Skin Diseases / drug therapy*
Tacrolimus / adverse effects*
Tacrolimus / analogs & derivatives*
Treatment Outcome

Substances

Tacrolimus