The trigeminal trophic syndrome: an unusual cause of nasal ulceration

J Am Acad Dermatol. 2004 Jun;50(6):949-52. doi: 10.1016/j.jaad.2004.01.038.


Trigeminal trophic syndrome (TTS) is an unusual complication after peripheral or central damage to the trigeminal nerve, characterized by anesthesia, paresthesias, and ala nasi ulceration. We describe a patient with classic TTS after trigeminal rhizotomy who underwent several extensive evaluations for nasal ulceration and received prolonged immunosuppressive therapy for a presumed autoimmune disorder before the correct diagnosis was made. An understanding of the predisposing factors and clinical presentation of TTS is important to ensure a timely diagnosis of this difficult-to-treat illness. Differentiation of TTS from malignancy, infection, or vasculitis is possible on the basis of clinical history, tissue biopsy, and serologic evaluation.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Female
  • Humans
  • Middle Aged
  • Nose Diseases / diagnosis
  • Nose Diseases / etiology*
  • Postoperative Complications
  • Syndrome
  • Trigeminal Nerve Injuries*
  • Ulcer / diagnosis
  • Ulcer / etiology*