Microcirculatory efficacy of topical treatment with aescin + essential phospholipids gel in venous insufficiency and hypertension: new clinical observations

Angiology. 2004 May-Jun;55 Suppl 1:S1-5. doi: 10.1177/000331970405500601.


Aescin + essential phospholipids (AEPL) topical gels are used for local treatment of venous and microcirculatory alterations (varicose veins, chronic venous insufficiency). Bruises, swelling, thrombophlebitis, and contusions are effectively treated with AEPL. Active ingredients are escinate and essential phospholipids (EPL). The aim of this new study was the evaluation of the efficacy of the effects of AEPL gel on the microcirculation in subjects with chronic venous insufficiency, venous hypertension (CVH), and venous microangiopathy. Patients were assessed measuring skin flux with laser-Doppler flowmetry (LDF). After 2 weeks of local treatment, all individual values (100%) were significantly decreased (p < 0.05), indicating an improvement in the microcirculation. In all treated patients, flux decreased at least 30% (indicating a decrease in the level of venous microangiopathy) (p < 0.05). Considering these observations, topical treatment with AEPL in areas of venous microangiopathy is beneficial, can prevent ulceration, and improves the skin healing processes.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial

MeSH terms

  • Administration, Topical
  • Adult
  • Aged
  • Drug Combinations
  • Escin / administration & dosage*
  • Female
  • Gels
  • Humans
  • Laser-Doppler Flowmetry
  • Leg / blood supply*
  • Male
  • Microcirculation / drug effects
  • Middle Aged
  • Phosphatidylcholines / administration & dosage*
  • Ultrasonography
  • Venous Insufficiency / diagnostic imaging
  • Venous Insufficiency / drug therapy*
  • Venous Insufficiency / physiopathology
  • Venous Pressure


  • Drug Combinations
  • Gels
  • Phosphatidylcholines
  • essential 303 forte
  • Escin