Biochem Soc Trans. 2004 Jun;32(Pt3):421-5. doi: 10.1042/BST0320421.


Anoikis is apoptosis induced by loss of cell adhesion or inappropriate cell adhesion. Adhesion on the extracellular matrix is important to determine whether a cell is in the correct location and to delete displaced cells by apoptosis. The ability to overcome this requirement has important implications for metastatic cancer. However, how adhesion signals are interpreted by a cell into a life or death decision is complex. In this paper, we will examine this from the point of view of the apoptotic machinery of the cell, and discuss the various ways in which adhesion can influence this process.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Anoikis*
  • Apoptosis
  • Cell Adhesion
  • Cell Survival
  • Extracellular Matrix / metabolism*
  • Humans
  • Models, Biological
  • Neoplasm Metastasis
  • Protein Structure, Tertiary
  • Proto-Oncogene Proteins c-bcl-2 / physiology
  • Signal Transduction


  • Proto-Oncogene Proteins c-bcl-2