Allodynia in Patients With Post-Stroke Central Pain (CPSP) Studied by Statistical Quantitative Sensory Testing Within Individuals

Pain. 2004 Jun;109(3):357-66. doi: 10.1016/j.pain.2004.02.002.

Abstract

The disinhibition hypothesis of post-stroke central pain (CPSP) suggests that 'the excessive response (dysesthesia/hyperalgesia/allodynia) is accompanied by a em leader loss of sensation' resulting from a lesion of a 'lateral nucleus' of thalamus or of 'cortico-thalamic paths' [Brain 34 (1911) 102]. One recent elaboration of this hypothesis proposes a submodality specific relationship, such that injury to a cool-signaling lateral thalamic pathway disinhibits a nociceptive medial thalamic pathway, thereby producing both burning, cold, ongoing pain and cold allodynia. The current study quantitatively evaluated the sensory loss and sensory abnormalities to discern submodality relationships between these sensory features of CPSP. The present results were statistically tested within individuals so that sensory loss and sensory abnormality are directly related by occurrence in the same individual. The results demonstrate that individuals with CPSP and normal tactile detection thresholds experience tactile allodynia significantly more often than those with tactile hypoesthesia. Most patients (11/13) exhibited hypoesthesia for the perception of cool stimuli, but few of these (2/11) showed cold allodynia. The most dramatic case of cold allodynia occurred in a patient who had a normal detection threshold for cold. Individuals with cold hypoesthesia, strictly contralateral to the cerebro-vascular accident (CVA or stroke), were often characterized by the presence of burning, cold, ongoing pain, and by the absence, not the presence, of cold allodynia. Overall, these results in CPSP suggest that tactile allodynia occurs in disturbances of thermal/pain pathways that spare the tactile-signaling pathways, and that cold hypoesthesia is neither necessary nor sufficient for cold allodynia.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Afferent Pathways / pathology
  • Afferent Pathways / physiopathology
  • Aged
  • Data Interpretation, Statistical
  • Female
  • Gyrus Cinguli / physiopathology
  • Humans
  • Hyperalgesia / diagnosis*
  • Hyperalgesia / etiology
  • Hyperalgesia / physiopathology*
  • Male
  • Middle Aged
  • Models, Neurological
  • Neural Inhibition / physiology
  • Neurologic Examination / standards
  • Pain, Intractable / diagnosis*
  • Pain, Intractable / etiology
  • Pain, Intractable / physiopathology*
  • Physical Stimulation
  • Sensation Disorders / diagnosis*
  • Sensation Disorders / etiology
  • Sensation Disorders / physiopathology*
  • Stroke / complications*
  • Syndrome
  • Thalamus / pathology
  • Thalamus / physiopathology
  • Thermosensing / physiology
  • Touch / physiology
  • Ventral Thalamic Nuclei / pathology
  • Ventral Thalamic Nuclei / physiopathology