Regulation of picornavirus gene expression

Microbes Infect. 2004 Jun;6(7):702-13. doi: 10.1016/j.micinf.2004.03.001.


Members of the Picornaviridae are positive- strand RNA viruses that cause a variety of human diseases such as poliomyelitis, the common cold, myocarditis, and hepatitis. Although the diseases caused by picornaviruses are diverse, the genome organization and mechanisms of gene expression are highly conserved among family members. This review will discuss the mechanisms of viral gene expression including cap-independent translation initiation, host cell translation shut off, viral polyprotein processing, and RNA replication.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Gene Expression Regulation, Viral*
  • Humans
  • Picornaviridae / genetics
  • Picornaviridae / metabolism
  • Picornaviridae / pathogenicity
  • Picornaviridae Infections / virology
  • RNA, Viral / biosynthesis
  • Viral Proteins / genetics
  • Viral Proteins / metabolism*
  • Virus Replication


  • RNA, Viral
  • Viral Proteins