Perspective on the safety and effectiveness of conjugated linoleic acid

Am J Clin Nutr. 2004 Jun;79(6 Suppl):1132S-1136S. doi: 10.1093/ajcn/79.6.1132S.


The amount of scientific literature on conjugated linoleic acid (CLA) is growing at a phenomenal rate. Animal studies and clinical trials indicate the possibility that CLA could be useful in improving human health in a number of areas, eg, controlling body fat gain and enhancing immunity while also reducing inflammation and other adverse effects typically associated with immune enhancement. The background of this growing research field and mechanistic insights from animal and cell culture experiments are briefly reviewed. Experimental and clinical data relating to the safety and effectiveness of CLA in humans are presented and discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adipose Tissue / drug effects
  • Animals
  • Body Composition / drug effects
  • Health Promotion
  • Humans
  • Immunity / drug effects
  • Inflammation / therapy
  • Linoleic Acids, Conjugated / adverse effects*
  • Linoleic Acids, Conjugated / chemistry
  • Linoleic Acids, Conjugated / therapeutic use*


  • Linoleic Acids, Conjugated