Na(+)-activated K+ channels are widely distributed in rat CNS and in Xenopus oocytes

Brain Res. 1992 Jul 3;584(1-2):319-21. doi: 10.1016/0006-8993(92)90913-t.


We recorded the activity of K+ channels activated by sodium (KNa channels) in two widely used preparations, primary cell cultures prepared from neocortex, cerebellum, midbrain, brainstem and spinal cord, and Xenopus oocytes. KNa channels from all regions shared an absolute dependence on [Na+], had conductances of 140-170 pS in symmetrical 150 mM K+ and exhibited characteristic substates. The role of this channel must now be considered in terms of its widespread distribution.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Central Nervous System / drug effects
  • Central Nervous System / metabolism*
  • Membranes / drug effects
  • Membranes / metabolism
  • Neuroglia / drug effects
  • Neuroglia / metabolism
  • Neurons / drug effects
  • Neurons / metabolism
  • Oocytes / drug effects
  • Oocytes / metabolism*
  • Potassium Channels / drug effects*
  • Rats
  • Sodium / pharmacology*
  • Xenopus


  • Potassium Channels
  • Sodium