Familial nasopharyngeal carcinoma in patients who are not Chinese

Cancer. 1992 Sep 1;70(5):1024-9. doi: 10.1002/1097-0142(19920901)70:5<1024::aid-cncr2820700503>3.0.co;2-4.


Background: Nasopharyngeal carcinoma (NPC) is a malignancy that is prominent in Cantonese Chinese people. It is presumed to result from an interaction of genetic and environmental factors, including the Epstein-Barr virus (EBV). In an attempt to further clarify the pathogenesis of this disease, an evaluation of NPC occurring in racial/ethnic groups not considered susceptible to this disease could be informative.

Methods: A white family with NPC occurring in three siblings was investigated and information was gleaned from literature on other reports of familial NPC in non-Chinese families.

Results: In the family being investigated, another genetically determined disease, hemophilia, was identified. Radiation early in life was noted to be a possible risk factor for NPC in the proband. A review of familial NPC in the white population revealed that in contrast to sporadic NPC, which is usually of the well-differentiated type, familial NPC usually is poorly differentiated.

Conclusions: Familial NPC offers an important opportunity to investigate the etiology of this disease. With newer laboratory techniques to investigate pathogenetic mechanisms, detailed evaluations of non-Chinese NPC families may become increasingly important.

Publication types

  • Case Reports
  • Comparative Study
  • Review

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • European Continental Ancestry Group*
  • Family Health
  • Female
  • Humans
  • Male
  • Middle Aged
  • Nasopharyngeal Neoplasms / genetics*
  • Pedigree
  • Risk Factors