Natural products active against African trypanosomes: a step towards new drugs

Nat Prod Rep. 2004 Jun;21(3):353-64. doi: 10.1039/b311021b. Epub 2004 May 5.

Abstract

This review covers compounds with activity on African trypanosomes (mainly Trypanosoma brucei subsp.,T congolense and T vivax) isolated from natural sources and is organized according to the structure of the etabolites (alkaloids, phenolic derivatives, quinones, terpenes and other metabolites). The literature from he mid-1980s up to June 2003 is reviewed and 89 references are cited.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Africa
  • Alkaloids / chemistry
  • Alkaloids / pharmacology
  • Animals
  • Biological Products / chemistry
  • Biological Products / pharmacology*
  • Molecular Structure
  • Phenols / chemistry
  • Phenols / pharmacology
  • Quinones / chemistry
  • Quinones / pharmacology
  • Terpenes / chemistry
  • Terpenes / pharmacology
  • Trypanosoma / drug effects*

Substances

  • Alkaloids
  • Biological Products
  • Phenols
  • Quinones
  • Terpenes