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Comparative Study
. 2004 May 27;429(6990):375-81.
doi: 10.1038/nature02462.

The DNA Sequence and Comparative Analysis of Human Chromosome 10

P Deloukas  1 M E EarthrowlD V GrafhamM RubenfieldL FrenchC A StewardS K SimsM C JonesS SearleC ScottK HoweS E HuntT D AndrewsJ G R GilbertD SwarbreckJ L AshurstA TaylorJ BattlesC P BirdR AinscoughJ P AlmeidaR I S AshwellK D AmbroseA K BabbageC L BagguleyJ BaileyR BanerjeeK BatesH BeasleyS Bray-AllenA J BrownJ Y BrownD C BurfordW BurrillJ BurtonP CahillD CamireN P CarterJ C ChapmanS Y ClarkG ClarkeC M CleeS CleggN CorbyA CoulsonP DhamiI DuttaM DunnL FaulknerA FrankishJ A FranklandP GarnerJ GarnettS GribbleC GriffithsR GrocockE GustafsonS HammondJ L HarleyE HartP D HeathT P HoB HopkinsJ HorneP J HowdenE HuckleC HyndsC JohnsonD JohnsonA KanaM KayA M KimberleyJ K KershawM KokkinakiG K LairdS LawlorH M LeeD A LeongamornlertG LairdC LloydD M LloydJ LovelandJ LovellS McLarenK E McLayA McMurrayM Mashreghi-MohammadiL MatthewsS MilneT NickersonM NguyenE Overton-LartyS A PalmerA V PearceA I PeckS PelanB PhillimoreK PorterC M RiceA RogosinM T RossT SarafidouH K SehraR ShownkeenC D SkuceM SmithL StandringN SycamoreJ TesterA ThorpeW TorcassoA TraceyA TromansJ TsolasM WallJ WalshH WangK WeinstockA P WestD L WilleyS L WhiteheadL WilmingP W WrayL YoungY ChenR C LoveringN K MoschonasR SiebertK FechtelD BentleyR DurbinT HubbardL Doucette-StammS BeckD R SmithJ Rogers
Affiliations
Comparative Study

The DNA Sequence and Comparative Analysis of Human Chromosome 10

P Deloukas et al. Nature. .

Abstract

The finished sequence of human chromosome 10 comprises a total of 131,666,441 base pairs. It represents 99.4% of the euchromatic DNA and includes one megabase of heterochromatic sequence within the pericentromeric region of the short and long arm of the chromosome. Sequence annotation revealed 1,357 genes, of which 816 are protein coding, and 430 are pseudogenes. We observed widespread occurrence of overlapping coding genes (either strand) and identified 67 antisense transcripts. Our analysis suggests that both inter- and intrachromosomal segmental duplications have impacted on the gene count on chromosome 10. Multispecies comparative analysis indicated that we can readily annotate the protein-coding genes with current resources. We estimate that over 95% of all coding exons were identified in this study. Assessment of single base changes between the human chromosome 10 and chimpanzee sequence revealed nonsense mutations in only 21 coding genes with respect to the human sequence.

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