The case for a US prospective cohort study of genes and environment

Nature. 2004 May 27;429(6990):475-7. doi: 10.1038/nature02628.


Information from the Human Genome Project will be vital for defining the genetic and environmental factors that contribute to health and disease. Well-designed case-control studies of people with and without a particular disease are essential for this, but rigorous and unbiased conclusions about the causes of diseases and their population-wide impact will require a representative population to be monitored over time (a prospective cohort study). The time is right for the United States to consider such a project.

MeSH terms

  • Case-Control Studies
  • Cohort Studies*
  • Environment*
  • Genetics, Medical / methods*
  • Genetics, Medical / trends*
  • Humans
  • Prospective Studies*
  • United States