Role of infiltrated leucocytes in tumour growth and spread

Br J Cancer. 2004 Jun 1;90(11):2053-8. doi: 10.1038/sj.bjc.6601705.


Leucocytes are a major component of the tumour microenvironment. Recent studies have indicated that the infiltration and activity of these host cells are regulated by the tumour to promote its survival and progression. Through the production of an array of growth factors, proteases and angiogenic mediators, leucocytes in the tumour microenvironment promote tumour growth, angiogenesis and metastasis.

Publication types

  • Review

MeSH terms

  • Disease Progression
  • Endopeptidases / biosynthesis
  • Endopeptidases / pharmacology
  • Humans
  • Leukocytes / physiology*
  • Lymphocytes, Tumor-Infiltrating / physiology*
  • Neoplasm Metastasis / physiopathology*
  • Neoplasms / blood supply
  • Neoplasms / immunology*
  • Neoplasms / physiopathology*
  • Neovascularization, Pathologic*


  • Endopeptidases