How to treat tremor

J Neurol. 2004 May;251(5):525-8. doi: 10.1007/s00415-004-0436-x.

Abstract

This paper presents an example of 18(th) century medical thinking. The author, Dr Georg Ernst Stahl (1659-1734) was the founder of the phlogiston theory in the field of chemistry, a medical professor, and a court physician in Saxony and Prussia. His description includes a definition of tremor, the internal and external causes of tremor, the types of tremor, the diagnostic and prognostic signs, and the treatment. From a present (contemporary) point of view, some compounds that were then used in treatment may have had a limited therapeutic effect on some kinds of tremor. Protopin has an anticholinergic and GABA-ergic effect, and rhoeadin (tetrahydrobenzazepin) may have had an effect similar to that of neuroleptics. Nevertheless, it is not clear whether the recommended quantity of these compounds was sufficient for a clinical effect. Most of the prescribed drugs could only have had a placebo effect.

Publication types

  • Biography
  • Historical Article

MeSH terms

  • Benzophenanthridines
  • Berberine Alkaloids / history
  • Berberine Alkaloids / therapeutic use
  • Cholinergic Antagonists / history
  • Cholinergic Antagonists / therapeutic use
  • Germany
  • History, 18th Century
  • Humans
  • Tremor / history*
  • Tremor / therapy

Substances

  • Benzophenanthridines
  • Berberine Alkaloids
  • Cholinergic Antagonists
  • protopine

Personal name as subject

  • Georg Ernst Stahl