Carbohydrate-electrolyte (E-Lyte) solution enhances bowel preparation with oral fleet phospho-soda

Dis Colon Rectum. 2004 Jul;47(7):1181-6. doi: 10.1007/s10350-004-0559-2. Epub 2004 Jun 3.


Purpose: Bowel preparation with oral sodium phosphate can cause symptomatic dehydration and electrolyte disturbances. This randomized, controlled trial was designed to evaluate whether carbohydrate-electrolyte (E-Lyte) solution enhanced bowel preparation and improved patient acceptance with oral sodium phosphate.

Methods: A total of 187 consecutive adults undergoing colonoscopy by two endoscopists were randomized to receive two packets of oral sodium phosphate (Fleet Phospho-soda) with or without additional supplement of a carbohydrate-electrolyte (E-Lyte) solution. All patients and endoscopists completed a standardized questionnaire. Urine-specific gravity and serum biochemistry were randomly performed in 150 and 50 patients, respectively.

Results: Ninety patients were randomized to have oral sodium phosphate with E-Lyte supplements (Group 1) and 94 patients to sodium phosphate without E-Lyte supplements (Group 2). The groups were similar in age and gender, indication for colonoscopy, and previous colonic surgery. Patients taking E-Lyte supplement had significantly less dizziness (none, 80 vs. 56 percent; P < 0.001) and a trend toward less nausea (none, 70 vs. 56 percent; P = 0.05). All patients in Group 1 completed the bowel preparation as opposed to 3 percent of Group 2 being unable to complete the preparation. Hypokalemia was significantly more frequent ( P = 0.008) in Group 2 patients without E-Lyte supplements. More patients in Group 2 needed intravenous rehydration (11 vs. 4 percent). Differences in serum creatinine and urine-specific gravity suggested possibly a lesser degree of hypovolemia in patients taking E-Lyte supplements. The quality of bowel cleansing in patients taking E-Lyte supplements was considered better by both the endoscopists and patients.

Conclusions: Carbohydrate-electrolyte (E-Lyte) solution protects against hypokalemia, improves patient tolerability, and may enhance use of oral sodium phosphate as a bowel-preparation agent.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Administration, Oral
  • Carbohydrates / administration & dosage
  • Cathartics / administration & dosage*
  • Colonoscopy
  • Electrolytes / administration & dosage
  • Female
  • Humans
  • Hypokalemia / prevention & control
  • Intestines / drug effects*
  • Male
  • Middle Aged
  • Patient Acceptance of Health Care
  • Phosphates / administration & dosage*
  • Preoperative Care / methods
  • Rehydration Solutions / administration & dosage*
  • Surface-Active Agents / administration & dosage*
  • Treatment Outcome


  • Carbohydrates
  • Cathartics
  • Electrolytes
  • Phosphates
  • Rehydration Solutions
  • Surface-Active Agents
  • sodium phosphate