Midline lethal granuloma--a clinical enigma

Indian J Dent Res. Jul-Sep 2003;14(3):174-83.


Midline Lethal granuloma is characterized by progressive destruction of nose, paranasal sinuses and palate. Till date, the diagnosis of this mutilating process remains as enigma due to the non specific histological and systemic findings. However, over the years the clinicians have been able to divide the "Lethal midline granuoloma syndrome" into clinical entities: Idiopathic midline destructive disease, Wegener's granulomatosis, polymorphic retiaculosis and Non-Hodgkins lymphoma. This article attempts to distinguish between these disease entities in the light of 2 case reports of Idiopathic midline destructive disease.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Diagnosis, Differential
  • Granuloma, Lethal Midline / classification
  • Granuloma, Lethal Midline / diagnosis*
  • Granulomatosis with Polyangiitis / diagnosis
  • Humans
  • Lymphatic Diseases / diagnosis
  • Lymphoma, Non-Hodgkin / diagnosis
  • Male